Showing posts with label Blood pressure. Show all posts
Showing posts with label Blood pressure. Show all posts

Friday, October 22, 2010

Stroke Identification

  •  What is a Stroke
  •  Symptoms
  •  How to prevent a stroke
  •  How to recognize 
  •  Treatment
  •  Life-threatening complications after a stroke



          Stroke, also called brain attack or cerebral infarction, is a very serious condition in which the brain is not receiving enough oxygen to function properly. Stroke often results in permanent serious complications and disability and is a common cause of death. It is the second leading cause of death worldwide and the third leading cause of death in the U.S., according to the American Heart Association.
There are actually two different kinds of strokes:
  • Ischemic strokes. These are the most common type of stroke. They happen when a blood clot blocks an artery, choking off oxygen to a part of the brain. Without oxygen, brain cells first go into shock and then start dying. So the longer you go without stroke treatment, the greater the damage to your brain.
    While not a full-fledged stroke, transient ischemic attacks (TIAs or "mini-strokes") cause stroke symptoms but resolve within a few minutes. We'll talk more about them later.
  • Hemorrhagic strokes. While less common, these strokes are more devastating. They're the result of a hemorrhage -- a burst blood vessel -- in the brain. Although the cause is very different from an ischemic stroke, the result is the same: Brain cells can't get the blood they need. More than 60% of people who have a hemorrhagic stroke die within a year, and those who survive tend to be much more disabled.
  • WATCH VIDEOS

Can you prevent a stroke?

After you have had a stroke, you are at risk for having another one. You can make some important lifestyle changes that can reduce your risk of stroke and improve your overall health.
  • Don't smoke. Smoking can more than double your risk of stroke. Avoid secondhand smoke too.
  • Eat a heart-healthy diet that includes plenty of fish, fruits, vegetables, beans, high-fiber grains and breads, and olive oil. Eat less salt too.
  • Try to do moderate activity at least 2½ hours a week. It's fine to be active in blocks of 10 minutes or more throughout your day and week. Your doctor can suggest a safe level of exercise for you.
  • Stay at a healthy weight.
  • Control your cholesterol and blood pressure.
  • If you have diabetes, keep your blood sugar as close to normal as possible.
  • Limit alcohol. Having more than 1 drink a day (if you are female) or more than 2 drinks a day (if you are male) increases the risk of stroke.
  • Take a daily aspirin or other medicines if your doctor advises it.
  • Avoid getting sick from the flu. Get a flu shot every year.
Work closely with your doctor. Go to all your appointments, and take your medicines just the way your doctor says to.
How are strokes treated

         Specific stroke treatment depends on the type of stroke. If caught in time, ischemic strokes can be treated with drugs called clot busters (thrombolytics). Clot busters can quickly dissolve the blockage, restoring blood flow to the affected area and preserving brain cells.
  •                Hemorrhagic strokes are difficult to treat -- usually, it's necessary to simply watch and wait for bleeding to stop on its own. Occasionally, hemorrhagic strokes can be treated with surgery or other procedures.
                  The main problem with treating strokes is catching them in time. Clot-busters need to be given within a few hours of the very first symptoms of a stroke.
                   As you recover -- and stroke recovery can be slow -- you're likely to need ongoing treatment. The problem is that having one stroke puts you at risk for having more. If you've had an ischemic stroke, your doctor might recommend blood thinners -- drugs that reduce your blood's tendency to clot. Stents can also be surgically implanted to open up a clogged artery.

    Life-threatening complications after a stroke

    Complications that threaten a person's life may develop soon after stroke symptoms occur. Preventing these complications is a major focus of initial stroke treatment.
    Life-threatening complications include:
          -Increased pressure on the brain, which develops when the brain swells after a large stroke. Such swelling occurs quickly, becomes most severe within 3 to 5 days after the stroke, and can cause death. Pressure on the brain is more likely in people who have had a stroke caused by a bleeding blood vessel (hemorrhagic stroke).
          -Fever. This may make a person's chance of recovery worse if the fever occurs at the same time as a stroke. Fever may be a sign of an infection, such as pneumonia or a urinary tract infection. Drugs that reduce fever (acetaminophen or aspirin) are often used. But if these do not work, a special blanket that circulates cool air or water may be needed.
          -High blood sugar (glucose). This often occurs in people who have diabetes. Very high or low blood sugar immediately after a stroke interferes with proper brain cell function, increasing the risk of damage.
          -Blood pressure changes. People who have a stroke usually will have higher blood pressure for at least 1 to 3 days after the stroke. This may represent an attempt by the body to increase blood flow to the part of the brain that is being affected by the stroke. Only very high blood pressure is treated. If it occurs, very high blood pressure usually is brought down slowly. A rapid drop in blood pressure can lead to more brain damage.
           -Buildup of spinal fluid within the brain (hydrocephalus). Fluid on the brain is more likely to occur if the stroke was caused by bleeding (hemorrhagic stroke).
           -Spasms of blood vessels (vasospasm). Vasospasm may occur if the stroke was caused by a subarachnoid hemorrhage from an aneurysm.
            -A blood clot in the legs (deep vein thrombosis) that may travel to the lungs (pulmonary embolism).
Seizures.
           -Another stroke.
           -Coma. 
Stroke Warning Signs:
If you notice one or more of these signs, don't wait. Stroke is a medical emergency. Call 9-1-1 or your emergency medical services. Get to a hospital right away!  
The American Stroke Association wants you to learn the warning signs of stroke:
  • Sudden numbness or weakness of the face, arm or leg, especially on one side of the body
  • Sudden confusion, trouble speaking or understanding
  • Sudden trouble seeing in one or both eyes
  • Sudden trouble walking, dizziness, loss of balance or coordination
  • Sudden, severe headache with no known cause
 Be prepared for an emergency.

  • Keep a list of emergency rescue service numbers next to the telephone and in your pocket, wallet or purse.
  • Find out which area hospitals are primary stroke centers that have 24-hour emergency stroke care.
  • Know (in advance) which hospital or medical facility is nearest your home or office.
Take action in an emergency.
  • Not all the warning signs occur in every stroke. Don't ignore signs of stroke, even if they go away!
  • Check the time. When did the first warning sign or symptom start? You'll be asked this important question later.
  • If you have one or more stroke symptoms that last more than a few minutes, don't delay! Immediately call 9-1-1 or the emergency medical service (EMS) number so an ambulance (ideally with advanced life support) can quickly be sent for you.
  • If you're with someone who may be having stroke symptoms, immediately call 9-1-1 or the EMS. Expect the person to protest — denial is common. Don't take "no" for an answer. Insist on taking prompt action.


[Case ]
STROKE IDENTIFICATION:
       During a BBQ, a woman stumbled and took a little fall - she assured everyone that she was fine (they offered to call paramedics). She said she had just tripped over a brick because of her new shoes.
They got her cleaned up and got her a new plate of food. While she appeared a bit shaken up, Jane went about enjoying herself the rest of the evening.
      Jane`s husband called later telling everyone that his wife had been taken to the hospital - at 6:00 pm Jane passed away. She had suffered a stroke at the BBQ. Had they known how to identify the signs of a stroke, perhaps Jane would be with us today. Some don`t die. They end up in a helpless, hopeless condition instead.
It only takes a minute to read this...
A neurologist says that if he can get to a stroke victim within 3 hours he can totally reverse the effects of a stroke,totally. He said the trick was getting a stroke recognized, diagnosed, and then getting the patient medically cared for within 3 hours, which is tough.
Source:
http://www.webmd.com/stroke/guide/stroke-topic-overview?page=2
http://www.wrongdiagnosis.com/s/stroke/symptoms.htm
http://www.medicinenet.com/stroke/article.htm

Tuesday, September 28, 2010

Libido and Aphrodisiacs (II)

 II. Aphrodisiacs

=are any of various forms of stimulation thought to arouse sexual excitement. Aphrodisiacs may be classified in two principal groups:

  • (1) psycho-physiological (visual, tactile, olfactory, aural)
  • (2) internal (stemming from food, alcoholic drinks, drugs, love potions, medical preparations).
      Despite long-standing literary and popular interest in internal aphrodisiacs, almost no scientific studies of them have been made. Scientific research is limited to occasional tests of drugs or hormones for the cure of male impotence. Most writings on the subject are little more than unscientific compilations of traditional or folkloric material. Of the various foods to which aphrodisiac powers are traditionally attributed, fish, vegetables, and spices have been the most popular throughout history. In none of these foods, however, have any chemical agents been identified that could effect a direct physiological reaction upon the genitourinary tract, and it must be concluded that the reputation of various supposedly erotic foods is based not upon fact but upon folklore.
         It has been suggested that man’s universal attribution of libidinous effects to certain foods originated in the ancient belief in the therapeutic efficacy of signatures: if an object resembled the genitalia, it possessed, so it was reasoned, sexual powers. Thus the legendary aphrodisiac powers of ginseng root and powdered rhinoceros horn.
         With the exception of certain drugs such as alcohol or marijuana, which may lead to sexual excitation through disinhibition, modern medical science recognizes a very limited number of aphrodisiacs.

Testosterone

Libido is clearly linked to levels of sex hormones, particularly testosterone. When a reduced sex drive occurs in individuals with relatively low levels of testosterone (e.g., post-menopausal women or men over age 60 ) ,testosterone supplements will often increase libido. Approaches using a number of precursors intended to raise testosterone levels have been effective in older males, but have not fared well when tested on other groups.
Yohimbine
Yohimbine is the main alkaloid of Yohimbe. Yohimbe, but not Yohimbine, is often popularly referred to as a "weak MAO inhibitor" although no sources are cited for this. Pharmaceutical preparations of yohimbine do not indicate that the drug, which is approved in the US for treatment of impotence (under such brand names as Yocon,Yohimex, Aphrodyne and Viritab), is an MAO inhibitor. Its main action is as an alpha-adrenergic antagonist, by which yohimbine may increase genital blood-flow and both sexual sensitivity and excitation in some people. Preparations of yohimbe bark are available over-the-counter and should be used with caution. The unrefined yohimbe bark contains several active alkaloids besides yohimbine. Side effects can include rapid pulse, sweating, and anxiety reactions in susceptible people. Pharmaceutical preparations of yohimbine can also produce these side effects at higher doses, but are available in standardized doses which allow the patient to dose in a controlled fashion. Some patients report a cumulative pro-sexual effect using the drug over time.

Bremelanotide

Some compounds that activate the melanocortin receptors MC3-R and MC4-R in the brain are effective aphrodisiacs. One compound from this class, bremelanotide, formerly known as PT-141, is undergoing clinical trials for the treatment of sexual arousal disorder and erectile dysfunction. It is intended for both men and women. Preliminary results have proven the efficacy of this drug, however development was briefly suspended due to a side effect of increased blood pressure observed in a small number of trial subjects who administered the drug intra-nasally. On August 12, 2009, Palatin, the company developing the drug, announced positive results (none of the previous heightened blood pressure effects were observed) of a phase I clinical study where trial subjects were instead administered the drug subcutaneously. Palatin is concurrently developing a related compound they call PL-6983.

Melanotan II

Melanotan II, bremelanotide's precursor has been demonstrated to have aphrodisiac properties.
PEA
There is some debate in lay circles as to whether a chemical called phenylethylamine present in chocolate is an aphrodisiac. There is some evidence to support the theory that phenethylamine release in the brain may be involved in sexual attraction and arousal but this compound is quickly degraded by the enzyme MAO and so it is unlikely that any significant concentrations would reach the brain when phenethylamine is taken orally.

Crocin

As per a new study, Crocin has demonstrated the properties of an aphrodisiac in rats.This is supported by pilot tests that demonstrate the efficacy of Saffron as an aphrodisiac.

Alkyl nitrites

Alkyl nitrites, (poppers), have a long history of use as a sexual enhancement aid, going back about fifty years. According to the text "Isobutyl nitrite and Related Compounds", many researchers agree that the alkyl nitrite may be a true aphrodisiac in the sense of promoting and enhancing sexual response.

Other drugs

Stimulants affecting the dopamine system such as cocaine and amphetamines (e.g. methamphetamine, aka crystal meth) are frequently associated with hyperarousal and hypersexuality, though both may impair sexual functioning, particularly with long term use.
Some directly acting dopamine agonists may also cause increased libido, although they can also cause various side effects. Pramipexole is the only dopamine agonist used in medicine as an aphrodisiac, and is sometimes prescribed to counteract the decrease in libido associated with SSRI antidepressant drugs. The older dopamine agonist apomorphine has been used for the treatment of erectile dysfunction, but is of poor efficacy and has a tendency to cause nausea. Other dopamine agonists such as bromocriptine and cabergoline may also be associated with increased libido, as can the dopamine precursor L-Dopa, but this is often part of a spectrum of side effects which can include mood swings and problem gambling and so these drugs are not prescribed for this purpose.
The libido-enhancing effects of dopamine agonists prescribed for other purposes has led to the development of a number of more selective compounds such as flibanserin, ABT-670 and PF-219,061, which have been developed specifically for the treatment of sexual dysfunction disorders, although none of them have yet passed clinical trials.

Drugs not considered aphrodisiacs

     Some psychoactive substances such as alcohol, cannabis, methaqualone, GHB and MDMA can increase libido and sexual desire. However these drugs are not aphrodisiacs in the strict sense of the definition, as they do not consistently produce aphrodisiac effects as their main action. However, these drugs are sometimes used to increase sexual pleasure and to reduce sexual inhibition.
Anti-erectile dysfunction drugs, such as Viagra and Levitra, are not considered aphrodisiacs because they do not have any direct effect on the libido, although increased ability to attain an erection may be interpreted as increased sexual arousal by users of these drugs.


Aphrodisiac foods and herbs

Some natural items purported to be aphrodisiacs when ingested or applied to the body.

Some newly introduced exotic foods often acquire such a reputation, at least until they become more familiar; for example:
  • Asparagus In 19th-century France, bridegrooms were served three courses of the vegetable at their prenuptial dinner
  • Bananas The sap of the red banana is considered an aphrodisiac in Central America
  • Tomatoes (allegedly to the French term pomme d'amour as a misrendering of pomme de Maure)
  • Truffles
  • Strawberries


Source:
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